Lisa (Nina Hoss), once a brilliant playwright, no longer writes. She lives with her family in Switzerland, but her heart remains in Berlin, beating in time with that of her twin brother Sven (Lars Eidinger), the famous theatre actor. Since Sven has been suffering from an aggressive type of leukemia, the relationship between them has become even closer. Lisa does not want to accept this blow of fate, she does everything in her power to bring Sven back on stage. For her soulmate, she neglects everything else and even risks losing her husband. Her marriage goes awry, but Lisa only has eyes for her brother, who reflects her deepest longings and awakens in her the desire to be creative, to feel alive again.